他达那非 | 171596-29-5

中文名称:他达那非
英文名称:Tadalafil
CAS No.:171596-29-5
分子式:C22H19N3O4 分子量:389.4040
山东万康生物科技有限公司
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山东海沃生物科技有限公司
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山东鲁宁药业有限公司
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chem960为您提供 321 他达那非生产厂家
简介
Tadalafil (IC-351) 是 PDE5 抑制剂,IC50 为 1.8 nM。
名称和标识符
  • MDL:MFCD07771966
  • InChIKey:WOXKDUGGOYFFRN-IIBYNOLFSA-N
  • Inchi:1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
  • SMILES:O=C1[C@@]2([H])C([H])([H])C3C4=C([H])C([H])=C([H])C([H])=C4N([H])C=3[C@@]([H])(C3C([H])=C([H])C4=C(C=3[H])OC([H])([H])O4)N2C(C([H])([H])N1C([H])([H])[H])=O
中文别名
  • 西力士
  • 他地那非
  • 他达那非
  • (6R-12aR)-6-(1,3-苯并二噁茂-5-基)-2-甲基-2,3,6,7,12,12a-六氢化吡嗪并[1',2'-1,6]-吡啶并[3,4-b]吲哚-1,4-二酮
  • ■他达那非
  • 豆浆香精
  • 高含量西力士 他达那非
  • 还阳碱
  • 酒溶他达那非(酒溶西力士)
  • 科研实验 他达那非
  • 临床实验他达那非
  • 溶酒抗检测氨基去甲基他达那非
  • 他达拉非
  • 他达拉非 EP标准品
  • 他达拉非 USP标准品
  • 他达拉非 标准品
  • 他达拉非(他达那非)
  • 他达拉非杂质 Tadalafil
  • 他达那非 (西力士)
  • 他达那非 标准品
  • 他达那非粉末
  • 他达那非固体状
  • 他达那非杂质对照品
  • 他达那非中间体
  • 他打那非
  • 他地拉非
  • 西地那非
  • 西力士 他达那非
  • 西力士(他达那非)
  • 西力士(他达那非)(甾体)
  • 西力士,他达那非中间体
  • 西力士Cialis (Tadalafil)
  • 西力士Tadalafil
  • 西力士杂质(他达那非)
  • 新阳碱
  • 医药级他达那非
  • 西力士他地那非
  • 限量出售他达那非
  • [ "Tadalafil", " 他达那非" ]
  • 西士力
  • 他拉那非
  • 西力士原粉
  • 他达那非原粉
  • 水溶性西力士
  • 他达那非杂质
  • 瓦地那非,伐地那非
  • 他达那非加纳粉提取物
  • 他达那非(标准品)
  • 可可棕色素
英文别名
  • Cialis
  • (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
  • Tadalafil
  • Cialis(Tadalafil)
  • Tadalafil solution
  • Calais
  • (6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a tetrahydropyrazino [1',2':1,6] pyrido[3,4b] indole1,4(6H,7H)-dione
  • Tadalafei
  • Tadanafil
  • Tildenafil
  • Cialis (Tadanafil)
  • IC 351
  • Adcirca
  • ICOS 351
  • GF 196960
  • UK 336017
  • Tadalafil iMpurity
  • Ic351
  • Tadalafil(Cialis)
  • 742SXX0ICT
  • TADALAFIL
  • CIALIS
  • (6R,12AR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido
  • Resistant to 95 test raw materials
  • Anti detection 94 health nourishing kidney raw materials
  • TADALAFIL COMPONENT OF ENTADFI
  • 1xoz
  • DB00820
  • TADALAFIL
  • CIALIS
  • HMS2051N17
  • ENTADFI COMPONENT TADALAFIL
  • Trans-tadalafil
  • NCGC00168781-01
  • A23556
  • PYRAZINO(1',2':1,6)PYRIDO(3,4-B)INDOLE-1,4-DIONE, 6-(1,3-BENZODIOXOL-5-YL)-2,3,6,7,12,12A-HEXAHYDRO-2-METHYL-, (6R-12AR)-
  • AB00639969-08
  • tadalafilum
  • TADALAFIL [EMA EPAR]
  • MLS001424132
  • CIA
  • AB00639969_09
  • Tadalafil (JAN/USP/INN)
  • LY450190
  • Adcirca (TN)
  • BDBM14777
  • Tadalafil mylan
  • (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1,2,1,6]pyrido[3,4-b]indole-1,4-dione
  • Tadalafil 100 microg/mL in Acetonitrile
  • SCHEMBL33333
  • DTXSID9046786
  • (6R,3,6,7,12,12a-Hexahydro-2-methyl-6-[3,4-(methylenedioxy)phenyl]pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
  • AR-270/43507798
  • ALYQ
  • (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
  • BRD-K93645900-001-04-8
  • WOXKDUGGOYFFRN-IIBYNOLFSA-N
  • TADALAFIL (MART.)
  • HY-90009A
  • (2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11,13,15-tetraene-4,7-dione
  • AB00639969_10
  • Tadalafil- Bio-X
  • HSDB 7303
  • (-)-Tadalafil (6R ,12aS) diastereomer
  • TADALAFIL [INN]
  • BT164435
  • Tox21_112642_1
  • (6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
  • ADCIRCA
  • NSC 759172
  • SW197603-2
  • 1242099-07-5
  • D02008
  • MLS001195644
  • TADALAFIL [ORANGE BOOK]
  • NSC759172
  • DTXCID7026786
  • (6R,12aR) 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
  • CCG-100973
  • Tadalafil specified impurity A
  • Tadalafil (6R ,12aS)- Lilly
  • TADALAFIL (USP-RS)
  • 171488-03-2
  • GF196960
  • LY-450190
  • G04BE08
  • (2R,8R)-2-(1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
  • TADALAFIL [VANDF]
  • Tadalafil 1.0 mg/ml in Acetonitrile
  • 6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1',2':1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE
  • Pharmakon1600-01505639
  • HMS2235L21
  • AB42193
  • HMS3884G19
  • SR-05000001940-1
  • (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1,2:1,6]pyrido[3,4-b]indole-1,4-dione
  • CHEBI:71940
  • Z1501485354
  • (2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione
  • (6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
  • Tadalafila
  • (-)-Tadalafil (6R)
  • GTPL7299
  • NSC-750236
  • Tadalafil (Cialis)
  • Pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-, (6R-trans)-
  • NCGC00263909-02
  • zalutia
  • TADALAFIL [MART.]
  • SR-05000001940
  • EX-A2644
  • 1,3-benzodioxol-5-yl(methyl)[?]dione
  • TADALAFIL (USP MONOGRAPH)
  • Tadalafil [USAN:INN:BAN]
  • (6R,12 aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
  • MLS001165782
  • SMR000466321
  • AKOS015892559
  • Cialis (TN)
  • Tadalafil [USAN]
  • TADALAFIL [WHO-DD]
  • (6R,12aR)-6-(Benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione
  • TADALAFIL [MI]
  • CHEMBL779
  • NSC-759172
  • Cialis, Tadalafil
  • TADALAFIL [JAN]
  • (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
  • TADALAFIL [USP-RS]
  • TADALAFIL [USP MONOGRAPH]
  • s1512
  • rel-(6R,12aR)-6-(Benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione
  • CS-1414
  • CAS-171596-29-5
  • (6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
  • MLS006010126
  • GF-196960
  • NSC 750236
  • Tadalafilo
  • Pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-, (6R,12aR)-
  • Pyrazino[1',6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12ahexahydro-2-methyl-, (6R,12aR)-
  • Tox21_112642
  • KS-1117
  • TADALAFIL [HSDB]
  • Q424156
  • TADLIQ
  • MLS000759426
  • Tadalafil Lilly
  • UNII-742SXX0ICT
  • TADALAFIL (EP MONOGRAPH)
  • TADALAFIL [EP MONOGRAPH]
  • NS00006532
  • 6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione
  • NSC750236
  • IC-351
  • MFCD07771966
  • (6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-(methylenedioxy)phenyl) pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
  • 171596-29-5
  • pyrazino
  • (6R,12aR) 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino [1',2':1,6] pyrido[3,4-b]indole-1,4-dione
  • AMY10321
  • NC00223
  • Zalutia (TN)
  • Cacao Pigment
计算特性
  • 精确分子量:389.13800
  • 氢键供体数量:1
  • 氢键受体数量:4
  • 可旋转化学键数量:1
  • 同位素质量:389.138
  • 重原子数量:29
  • 复杂度:702
  • 同位素原子数量:0
  • 确定原子立构中心数量:2
  • 不确定原子立构中心数量:0
  • 确定化学键立构中心数量:0
  • 不确定化学键立构中心数量:0
  • 共价键单元数量:1
  • 疏水参数计算参考值(XlogP):2.3
  • 拓扑分子极性表面积:74.9
实验特性
  • LogP:2.08710
  • PSA:74.87000
  • 折射率:1.705
  • 沸点:679.1°C at 760 mmHg
  • 熔点:296-303°C
  • 蒸气压:0.0±2.1 mmHg at 25°C
  • 闪点:2℃
  • 溶解度:DMSO: soluble20mg/mL, clear
  • 颜色与性状:Powder
  • 溶解性:在水中,25℃ 条件下估计220 mg/L
  • 比旋光度:+71° (c=1, CHCl3)
  • 密度:1.5±0.1 g/cm3
国际标准相关数据
  • EINECS:7303
生产方法和用途
  • 用途:磷酸二酯酶5抑制剂,用于治疗男性勃起功能障碍。
专业数据库参考
参考资料
  • Beilstein:200-835-2
相关文献
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  • 2. Doubly charged trimeric cluster ions: effective in mutual chiral recognition of tadalafil and three proton pump inhibitors Lu Wang,Yunfeng Chai,Wenquan Zhu,Yuanjiang Pan,Cuirong Sun,Su Zeng Analyst 2017 142 745
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