丙酸睾酮 | 57-85-2

中文名称:丙酸睾酮
英文名称:Testosterone propionate
CAS No.:57-85-2
分子式:C22H32O3 分子量:344.4877
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简介
       丙酸睾酮(testosterone propionate)雄激素类药,临床适用于无睾症、隐睾症、男性性腺机能减退症;妇科疾病如月经过多、子宫肌瘤;老年性骨质疏松以及再生障碍性贫血等。
名称和标识符
  • MDL:MFCD00003653
  • InChIKey:PDMMFKSKQVNJMI-BLQWBTBKSA-N
  • Inchi:1S/C22H32O3/c1-4-20(24)25-19-8-7-17-16-6-5-14-13-15(23)9-11-21(14,2)18(16)10-12-22(17,19)3/h13,16-19H,4-12H2,1-3H3/t16-,17-,18-,19-,21-,22-/m0/s1
  • SMILES:O(C(C([H])([H])C([H])([H])[H])=O)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])C([H])([H])C4=C([H])C(C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@@]21C([H])([H])[H])=O
中文别名
  • 丙酸睾酮
  • 丙睾
  • 丙酸睾丸酮
  • 丙酸睾丸素
  • 丙酸睾丸甾酮
  • 睾丸激素丙酸酯
  • 丙酸睾丸激素
  • 17丙酸睾丸激素
  • 甲酸睾丸酮
  • 丙酸睾酮 标准品
  • 丙酸睾酮(甾体)
  • 丙酸睾酮标准品(JP)
  • 丙酸睾酮甲醇溶液标准物质
  • 丙酸睾酮酯
  • 甲醇中丙酸睾酮溶液标准物质
  • 异己酸睾酮杂质C(EP) 标准品
英文别名
  • testosterone propionate
  • Ethylsecodione
  • Ethyldione
  • Testosterone-17-propionate
  • 17-(1-Oxopropoxy)-(17b)-androst-4-en-3-one
  • TESTOSTERON
  • PROPIONATE
  • TESTOSTERON 17-PROPIONATE
  • TESTOSTERONE 17-PROPIONATE
  • PROPIONIC ACID (8R,9S,10R,13S,14S,17S)-10,13-DIMETHYL-3-OXO-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL ESTER
  • 17-(1-oxopropoxy)-(17-beta)-androst-4-en-3-on
  • 17-[(1-Oxopropanoyl)oxy]androst-4-en-3-one
  • 3-Oxoandrost-4-en-17-ylpropionate
  • Agovirin
  • Androgen
  • Androlon
  • Andronate
  • Androsan
  • Androst-4-en-3-one, 17-(1-oxopropoxy)-, (17beta)-
  • Androst-4-en-3-one, 17beta-hydroxy-, propionate
  • Androsteston
  • [(8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl] propanoate
  • 2,3,5-Tribromothiophene
  • Testosterone (propionate)
  • Testosterone Propionate Solution
  • 17β-Hydroxy-4-androsten-3-one 17-propionate
  • 17β-Propionyloxy-4-androsten-3-one
  • 4-Androsten-17β-ol-3-one 17-propionate
  • Hormoteston
  • Aquaviron
  • Androteston
  • Enarmon
  • Bio-testiculina
  • Androtest P
  • Sterandryl
  • Testonique
  • Testoxyl
  • Testosid
  • Testogen
  • Testodrin
  • Telipex
  • Propiokan
  • Uniteston
  • Tostrin
  • Testormol
  • Synandrol
  • Testolets
  • Synerone
  • Solvotest
  • Pantestin
  • Orchistin
  • Masenate
  • Testrex
  • Testodet
  • Testaform
  • Orchiol
  • Nasdol
  • Vulvan
  • Enarmon-oil
  • Okasa-Mascul
  • Neo-Hombreol
  • Andrusol-P
  • Oreton propionate
  • Testex
  • Recthormone testosterone
  • T
  • Testosterone propionate
计算特性
  • 精确分子量:344.23500
  • 氢键供体数量:0
  • 氢键受体数量:3
  • 可旋转化学键数量:3
  • 同位素质量:344.235145
  • 重原子数量:25
  • 复杂度:621
  • 同位素原子数量:0
  • 确定原子立构中心数量:6
  • 不确定原子立构中心数量:0
  • 确定化学键立构中心数量:0
  • 不确定化学键立构中心数量:0
  • 共价键单元数量:1
  • 疏水参数计算参考值(XlogP):4.4
  • 互变异构体数量:5
  • 表面电荷:0
  • 拓扑分子极性表面积:43.4
实验特性
  • LogP:4.84010
  • PSA:43.37000
  • Merck:13,9255
  • 折射率:1.5000 (estimate)
  • 水溶性:<0.1 g/100 mL at 24.5 ºC
  • 沸点:419.57°C (rough estimate)
  • 熔点:118 ºC
  • 闪点:196.3°C
  • 溶解度:ethanol: 10 mg/mL
  • 颜色与性状:白色结晶
  • 溶解性:易溶于乙醇、乙醚、吡啶和其他有机溶剂,溶于植物油,不溶于水
  • 敏感性:光敏感性固体
  • 比旋光度:D25 +83 to +90° (100 mg in 10 ml dioxane)
  • 密度:1.0906 (rough estimate)
国际标准相关数据
  • EINECS:9166
海关数据
  • 海关数据:

    中国海关编码:

    2937290090
生产方法和用途
  • 用途:

    一,为人工合成的雄性激素,用于月经过多,功能性子宫出血,再障贫血,老年骨质疏松等。

    二,用于绝经前或绝经5年以内的晚期癌症。

    三,尚可用于子营肌瘤、卵巢癌、肾癌、多发性骨髓瘤等。

    四,生化研究

  • 生产方法:

    睾酮在吡啶的存在下用丙酰氯酰化而制得。

专业数据库参考
参考资料
  • Beilstein:3221760
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